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The nicotinamide mononucleotide (NMN), a phosphorylated intermediate in the synthesis of NAD can also be considered as a precursor since exogenous NMN administration raises NAD levels in various cell lines and tissues [68], and an NMN transporter (Slc12a8) has recently been identified in the murine small intestine [69]

No participants developed antibodies against the peptide, and no serious adverse events led to treatment withdrawal

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To minimize gastrointestinal side effects, clinicians start semaglutide at a low dose and titrate slowly, maintaining stable levothyroxine dosing until weight stabilizes